Male Infertility and Glutathione

Are You Half The Man Your Father Was?

It is a well-known fact that sperm counts have dropped by half in the last 50 years, and that modern men have 20 percent less semen volume than their fathers (BMJ, 1992, volume 305).

A recent report from researchers in Aberdeen presented preliminary data that suggests the sperm concentration of the men seen in their clinic had declined by 29% over the past 14 years. (British Fertility Society; 5 January 2004)

Persistent organic pollutants (POPs) and endocrine-disrupting chemicals from normal, everyday plastics are known to cause reproductive damage, as documented in Theo Colborn's book "Our Stolen Future."

Damage to sperm caused by exposure to common chemicals like alcohol, pesticides in food, has been linked to lowered intelligence and behavioral disorders in children.

Lifestyle risk factors known to decrease sperm quality include

> Cigarette smoking

> Alcohol consumption

> Chronic stress

> Nutritional deficiencies.

Other reasons for infertility include congenital factors, and health conditions like prostatitis and diabetes that can affect sperm production.

Pollution is stealing our future, and there's little anyone can do to avoid it. There may not be a lot you can do to reduce your exposure to persistent environmental toxins.

But there are definite measures you can take to reduce the impact of the environmental pollutants and toxins on your body.

You can prevent and, to a certain extent, repair the damage they cause to your body, through a better lifestyle and nutrition.

Some nutritional therapies and antioxidants that have proven beneficial in treating male infertility and improving sperm counts, sperm morphology and motility include:

> Carnitine

> Arginine

> Zinc

> Selenium

> Vitamin B-12

> Vitamin C

> Vitamin E

> Glutathione

> Coenzyme Q10

Studies show that anti-oxidant supplementation - glutathione in particular - can improve sperm quality, and possibly increase your chances of conceiving.

If you smoke, drink, are exposed to stress, chemicals, radiation, pesticides or take medication or drugs (like sulfasalazine, ketoconazole, azulfidine, anabolic steroids, marijuana) that affect fertility, you should consider taking an antioxidant supplement to reverse some of the damage.

Why are Antioxidants Important for Sperm Quality?

Mammalian spermatozoa are coated by a membrane rich in polyunsaturated fatty acids. These fatty acids are extremely susceptible to oxidative damage by free radicals or Reactive Oxygen Species (ROS) by a process called lipid peroxidation (LPO).

Lipid peroxidation damages the sperm cell membrane. It is considered to be the key mechanism of ROS-induced sperm damage and leads to

> Loss of sperm motility

> Abnormal sperm morphology

> Reduced capacity for oocyte penetration

> Infertility

To protect sperm from damage, the body depends on powerful antioxidant enzymes in the body such as superoxide dismutase (SOD), catalase, and glutathione peroxidase/reductase (GPX/GRD).

Seminal plasma and spermatozoa have several antioxidant enzymes - glutathione peroxidase, glutathione reductase, superoxide dismutase.

Some amount of all the antioxidant enzymes, which may protect spermatozoa from oxidative attack, are also made by the epididymis during storage.

The glutathione peroxidase/reductase enzymes play a central role in the defense against oxidative damage in human sperm.

Why is Glutathione important for Sperm Quality and Fertility?

A decrease in levels of reduced glutathione (GSH) during sperm production is known to disrupt the membrane integrity of spermatozoa due to increased oxidative stress.

Intracellular glutathione levels of spermatozoa are known to be decreased in certain populations of infertile men. Compared with a control group, the infertile men in all groups had significantly higher levels of ROS and lower levels of total antioxidants.

There is strong clinical evidence to show that men diagnosed with infertility have high levels of oxidative stress that may impair the quality of their sperm.

In some groups, higher levels of ROS were associated with lower sperm counts and defective sperm structure, while lower antioxidant levels correlated with reduced sperm movement.

Previous evidence has also shown that oxidative stress can decrease a sperm's life span, its motility, and its ability to penetrate the oocyst, or egg cell.

Up to 40% of men with unexplained male infertility have higher levels of free radical activity in their bodies.

Because men with high levels of ROS have a seven-fold lower likelihood of inducing a pregnancy than men with lower levels, researchers recommend that treatment for infertile men should include strategies to reduce oxidative stress and improve sperm quality.

How can Glutathione help in the Treatment of Infertility?

Glutathione is not only vital to sperm antioxidant defenses, but selenium and glutathione are essential to the formation of "phospholipid hydroperoxide glutathione peroxidase" - an enzyme present in spermatids - which becomes a structural protein in the mid-piece of mature spermatozoa.

When either substance is deficient, it can lead to instability of the mid-piece of the spermatozoa, resulting in defective motility.

Free radical scavengers - such as glutathione - that restore the structure and function of poly-unsaturated fatty acids (PUFA) in the cell membrane, can be used to treat these cases.

In a double-blind cross-over study of twenty infertile men, treatment with glutathione led to a statistically significant improvement of the sperm quality.

The study concerned men in whom the sperm quality was poor due to unilateral varicocele or germ-free genital tract inflammation - two conditions in which ROS or other toxic compounds are indicated as causative factors.

Treatment with glutathione was also found to have a statistically significantly positive effect on sperm motility (in particular forward motility) and on sperm morphology.

The findings of these studies indicate that glutathione therapy could represent a possible therapeutical tool in cases where ROS or exposure to toxins is the probable cause of infertility.

Read the complete report with references on male infertility and glutathione

Copyright ? 2004 Priya Shah

_____________________________________________

About the author:
Priya Shah is the Editor of male infertility and glutathione, a newsletter featuring regular updates on the health benefits of glutathione. Get a male infertility and glutathione
____________________________________________

taxi to Midway Barnhill ..
In The News:

AT&A announced a data breach that affected nearly all of the company's cellular customers, raising serious concerns about customer privacy and security.
Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents now and for the future.
Dave is the world's most advanced artificial intelligence Lego robotic head from Creative Mindstorms that combines toy blocks with cutting-edge AI technology.
Security robot Athena from Kody Robots is like a superhero among surveillance robots with brains of the most advanced artificial intelligence.
Researchers found the largest password leak ever with 10 billion unique passwords. Kurt “CyberGuy" Knutsson discusses how this a wake-up call for everyone who uses the internet.
Kurt “CyberGuy" Knutsson discusses how Kodiak Robotics’ tech may transform commercial/military transport.
Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents now and for the future.
Twilio confirmed to CyberGuy that hackers got access to 33 million phone numbers related to its Authy two-factor authentication service.
EOS-X Space, a Spanish company, is preparing to launch a luxury balloon capsule into near-space in 2025, allowing travelers to float to the stratosphere.
Scammers' newest frontier is real-estate — and bad actors finding targeting homeowners, buyers and sellers with their familiar dirty tricks.
Kurt “CyberGuy" Knutsson’s Prime Day guide: Top savings tips and cheap membership tricks.
Tech expert Kurt “CyberGuy" Knutsson gives straightforward steps to seamlessly pair your Apple Watch with a new iPhone and to transfer your data and settings.
Clever cyberattack targets 1.4 billion Apple iPhone users. Tech expert Kurt “CyberGuy" Knutsson reveals how to protect yourself against this spreading text phishing scam.
A driver became stranded on a Utah mountain last week after taking a shortcut using Google Maps, which led him to a dirt and rugged road, according to officials.
Kurt “CyberGuy" Knutsson on an AI-inspired wooden time car: A marvel of skill and tech.
Even though Apple AirTags are primarily designed for iPhones, Android users can use apps like Tracker Detect to scan for nearby AirTags.
Google's Circle to Search tool allows Android users to search anything on a screen without switching apps. The tool is activated by long-pressing the home button or navigation bar.
A new variant of the Android banking Trojan Medusa targeting financial institutions has returned, and it appears to be more savvy, according to the CyberGuy.
Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents now and for the future.
Technology wizard Kurt "CyberGuy" Knutsson explores some of the more obscure alternative security features to lock down your Windows PC.
Waabi’s AI advances self-driving trucks with generative tech. Kurt “CyberGuy" Knutsson takes a closer look at the new kid on the self-driving block.
Drones are now competing with traditional fireworks as the go-to option for pyrotechnic shows for events and holidays like the Fourth of July.
Technology expert Kim Komando shares 20 great tech shortcuts for our devices that get new updates and features — learn how to move with the curve.
Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents now and for the future.
People over the age of 60 lost a whopping $3.4 billion to scams in 2023, an increase of nearly 11% from the previous year, according to the FBI.

Compulsive Eating Alternative: Learning to Eat With Pleasure

Do you allow pleasure from food? Are your senses throughly... Read More

How To Treat and Prevent Low Carb Diet Headaches

Strict "no carb" phases of low carb diets have developed... Read More

Nutrition N Diet

Nutrition facts have become a part of everyday life because... Read More

Why You Should Eat Healthier

Every where you look you see articles or news or... Read More

Beans - The Perfect Food?

Beans. Legumes. Pulses. Whatever you call this plant group, they... Read More

Five Steps to a Healthier Heart

Step 1: Eat five to ten servings per day of... Read More

The Magic in Food: LOVE

Remember the old adage, you are what you eat? The... Read More

Homeostasis and Complementary Therapies

The word 'homeostasis' is made up of two Greek words:... Read More

What is A Balanced Diet For Losing Weight and Good Health?

The total calories that you should be consuming depend on... Read More

The Versatility of Actinase Protein Complex

The ingredients list found on the back or side panel... Read More

The Top 10 Ways to Improve Your Diet, Your Health & Your Life!

Because I believe diet and exercise are so important, I'm... Read More

Why Fad Diets Don?t Work

Fad diets have been around for more than 50 years... Read More

ACAI Berry Named Top 10 Superfoods For Anti-Aging by Dr. Nicholas Perricone

The benefits from eating healthy are endless. And, according to... Read More

Copping Out the Positive Effects of Copper

One must always keep in mind that copper is not... Read More

Alkalize Your Way to Better Health

Today we're shifting our focus from wealth to health. First... Read More

Blueberry Picking Techniques

First of all you have to have a bucket. You... Read More

How Can I Uncover Hidden Sugar And Prevent Carb Creep?

Many low carb dieters fall victim to "carb creep," which... Read More

Functional Foods Are Becoming More Popular...

Established in 1989 by Stephen DeFelice, "Foundation for Innovation in... Read More

The New Biology of Health ? the Way to Perpetual Youth?

Just what is the "New Biology of Health?" And who's... Read More

Minerals, Minerals, Minerals

You are a mineral bodyEvery part of you is made... Read More

True Culprits of High Cholesterol

What if I told you tap water and homogenized milk... Read More

Food for Healthy Nails

Nails are a protective horn at the end of our... Read More

Antioxidants - Add a Lean, Muscular Body to the List of Benefits!

I'm sure by now you've heard all about the amazing... Read More

Glycemic Index of Foods

All carbohydrates are not the same. Generally it is assumed... Read More

Nuts To You... Just One Way to a Healthy Heart

Nuts are readily available and provide a highly nutritious food.... Read More

limo service at o'hare Berkeley ..