Home
>
Nutrition
>
Male Infertility and Glutathione

Male Infertility and Glutathione

Are You Half The Man Your Father Was?

It is a well-known fact that sperm counts have dropped by half in the last 50 years, and that modern men have 20 percent less semen volume than their fathers (BMJ, 1992, volume 305).

A recent report from researchers in Aberdeen presented preliminary data that suggests the sperm concentration of the men seen in their clinic had declined by 29% over the past 14 years. (British Fertility Society; 5 January 2004)

Persistent organic pollutants (POPs) and endocrine-disrupting chemicals from normal, everyday plastics are known to cause reproductive damage, as documented in Theo Colborn's book "Our Stolen Future."

Damage to sperm caused by exposure to common chemicals like alcohol, pesticides in food, has been linked to lowered intelligence and behavioral disorders in children.

Lifestyle risk factors known to decrease sperm quality include

> Cigarette smoking

> Alcohol consumption

> Chronic stress

> Nutritional deficiencies.

Other reasons for infertility include congenital factors, and health conditions like prostatitis and diabetes that can affect sperm production.

Pollution is stealing our future, and there's little anyone can do to avoid it. There may not be a lot you can do to reduce your exposure to persistent environmental toxins.

But there are definite measures you can take to reduce the impact of the environmental pollutants and toxins on your body.

You can prevent and, to a certain extent, repair the damage they cause to your body, through a better lifestyle and nutrition.

Some nutritional therapies and antioxidants that have proven beneficial in treating male infertility and improving sperm counts, sperm morphology and motility include:

> Carnitine

> Arginine

> Zinc

> Selenium

> Vitamin B-12

> Vitamin C

> Vitamin E

> Glutathione

> Coenzyme Q10

Studies show that anti-oxidant supplementation - glutathione in particular - can improve sperm quality, and possibly increase your chances of conceiving.

If you smoke, drink, are exposed to stress, chemicals, radiation, pesticides or take medication or drugs (like sulfasalazine, ketoconazole, azulfidine, anabolic steroids, marijuana) that affect fertility, you should consider taking an antioxidant supplement to reverse some of the damage.

Why are Antioxidants Important for Sperm Quality?

Mammalian spermatozoa are coated by a membrane rich in polyunsaturated fatty acids. These fatty acids are extremely susceptible to oxidative damage by free radicals or Reactive Oxygen Species (ROS) by a process called lipid peroxidation (LPO).

Lipid peroxidation damages the sperm cell membrane. It is considered to be the key mechanism of ROS-induced sperm damage and leads to

> Loss of sperm motility

> Abnormal sperm morphology

> Reduced capacity for oocyte penetration

> Infertility

To protect sperm from damage, the body depends on powerful antioxidant enzymes in the body such as superoxide dismutase (SOD), catalase, and glutathione peroxidase/reductase (GPX/GRD).

Seminal plasma and spermatozoa have several antioxidant enzymes - glutathione peroxidase, glutathione reductase, superoxide dismutase.

Some amount of all the antioxidant enzymes, which may protect spermatozoa from oxidative attack, are also made by the epididymis during storage.

The glutathione peroxidase/reductase enzymes play a central role in the defense against oxidative damage in human sperm.

Why is Glutathione important for Sperm Quality and Fertility?

A decrease in levels of reduced glutathione (GSH) during sperm production is known to disrupt the membrane integrity of spermatozoa due to increased oxidative stress.

Intracellular glutathione levels of spermatozoa are known to be decreased in certain populations of infertile men. Compared with a control group, the infertile men in all groups had significantly higher levels of ROS and lower levels of total antioxidants.

There is strong clinical evidence to show that men diagnosed with infertility have high levels of oxidative stress that may impair the quality of their sperm.

In some groups, higher levels of ROS were associated with lower sperm counts and defective sperm structure, while lower antioxidant levels correlated with reduced sperm movement.

Previous evidence has also shown that oxidative stress can decrease a sperm's life span, its motility, and its ability to penetrate the oocyst, or egg cell.

Up to 40% of men with unexplained male infertility have higher levels of free radical activity in their bodies.

Because men with high levels of ROS have a seven-fold lower likelihood of inducing a pregnancy than men with lower levels, researchers recommend that treatment for infertile men should include strategies to reduce oxidative stress and improve sperm quality.

How can Glutathione help in the Treatment of Infertility?

Glutathione is not only vital to sperm antioxidant defenses, but selenium and glutathione are essential to the formation of "phospholipid hydroperoxide glutathione peroxidase" - an enzyme present in spermatids - which becomes a structural protein in the mid-piece of mature spermatozoa.

When either substance is deficient, it can lead to instability of the mid-piece of the spermatozoa, resulting in defective motility.

Free radical scavengers - such as glutathione - that restore the structure and function of poly-unsaturated fatty acids (PUFA) in the cell membrane, can be used to treat these cases.

In a double-blind cross-over study of twenty infertile men, treatment with glutathione led to a statistically significant improvement of the sperm quality.

The study concerned men in whom the sperm quality was poor due to unilateral varicocele or germ-free genital tract inflammation - two conditions in which ROS or other toxic compounds are indicated as causative factors.

Treatment with glutathione was also found to have a statistically significantly positive effect on sperm motility (in particular forward motility) and on sperm morphology.

The findings of these studies indicate that glutathione therapy could represent a possible therapeutical tool in cases where ROS or exposure to toxins is the probable cause of infertility.

Read the complete report with references on male infertility and glutathione

_____________________________________________

About the author:
Priya Shah is the Editor of male infertility and glutathione, a newsletter featuring regular updates on the health benefits of glutathione. Get a male infertility and glutathione
____________________________________________

housekeepers near Des Plaines ..

In The News:

As 18 states implement bell-to-bell cell phone bans, creative students use Google Docs, iMessage on MacBooks and Post-It notes to stay connected in class.

A sheriff's captain says deputies often spend hours writing reports between calls, but Axon's AI program, Draft One, helps them save crucial time in the field.

Sora 2, OpenAI's new video-generation app, can create AI-generated videos based on a singular prompt. The results are both mind-blowing and terrifying.

iPhone and Android users can reduce Wi-Fi calling battery drainage through settings adjustments, background app limits and stronger Wi-Fi connections.

Work email scams are becoming harder to detect as criminals use AI and spoofed addresses to trick employees into opening malicious attachments and links.

From her Arizona living room, Christina Chapman ran a covert hub that helped North Korean operatives infiltrate U.S. firms, netting $17 million in stolen salaries.

UC Santa Barbara researchers developed a soft robotic intubation system that achieved 100% success rates for experts and 96% for paramedics with minimal training.

Scammers exploit probate filings to target grieving families with fake fees and debts, Kurt "Cyberguy" Knutsson reports.

Automotive giant Stellantis becomes latest victim of widespread Salesforce breaches affecting companies like Google, Cisco and Adidas this year.

A woman from Washington reunited with her missing Maine Coon cat Louie after 11 days using Love Lost, a free AI-powered pet recovery platform.

Expert cybersecurity tips help Mac owners remove malware infections and strengthen defenses with antivirus software, password managers and system updates.

Meta's AI chatbot training rules bans sexual roleplay with minors and block access to child abuse material as regulators scrutinize its safety measures.

Online banking users face a new threat: web injection scams that overlay fake pop-ups to steal logins. Here’s how to spot them and protect your accounts.

Meta introduced Teen Accounts to Facebook and Messenger while launching a School Partnership Program for U.S. educators to report bullying within 48 hours.

Executive order signed by President Donald Trump tasks Robert F. Kennedy Jr.'s MAHA Commission with using AI to find new cures for childhood cancers.

New FileFix attack tricks Facebook and Instagram users into running malicious PowerShell commands disguised as Meta account maintenance to deploy StealC infostealer.

Step-by-step instructions help users migrate to Windows 11 while preserving emails, contacts, documents, and software licenses during the transition.

Chrome faces its sixth zero-day attack in 2025 as Google patches critical V8 engine flaw CVE-2025-10585 discovered by Threat Analysis Group.

The Hypershell X Ultra exoskeleton features 12 terrain modes and carbon fiber construction to enhance hiking, cycling and outdoor adventures.

Personal data from public records and data brokers helps scammers create tailored scam stories, making their calls and emails more believable to potential victims.

Uber Eats partners with drone delivery startup Flytrex to test autonomous food delivery services in U.S. markets, marking the company's first investment in drone technology.

OpenAI announces 120-day plan to strengthen ChatGPT safeguards for teens, including parental controls and expert council on AI wellbeing.

Spam emails can help improve security — if reported correctly. Learn how to report spam across major email services and get key tips to protect your inbox and personal data.

Harvard researcher Avi Loeb says comet 3I/ATLAS weighs 33 billion tons and spans 3.1 miles, making it far larger than previous interstellar visitors.

The Glassboro Public School District in New Jersey has partnered with ZeroEyes and InformaCast to detect visible firearms and alert staff and law enforcement within seconds.