Home
>
Nutrition
>
Dietary Sources of Glutathione

Dietary Sources of Glutathione

DIETARY SOURCES OF GLUTATHIONE: Glutathione (GSH) is an antioxidant and detoxifying agent whose protective role has been demonstrated in numerous clinical studies. GSH is synthesized rapidly in the liver, kidneys, and other tissues of the body, including the gastrointestinal tract. This process is effected by aging and disease, as both of these conditions result in reduced tissue and blood levels of glutathione. Dietary forms of glutathione are efficiently absorbed into the blood, however the same is not true for glutathione supplements in humans.

When healthy subjects were given a single dose of up to 3,000 mg of glutathione researchers found there was no increase in blood glutathione levels. (Witschi A, Reddy S, Stofer B, Lauterburg BH. The systemic availability of oral glutathione. Eur J Clin Pharmacol 1992;43(6):667-9.) The authors of this study concluded "it is not feasible to increase circulating glutathione to a clinically beneficial extent by the oral administrating of a single dose of 3 g of glutathione." Johnson and coworkers (Johnston CJ, Meyer CG, Srilakshmi JC. Vitamin C elevates red blood cell glutathione in healthy adults. Am J Clin Nutr 58:103-5, 1993) found that blood glutathione levels rose nearly 50% in healthy individuals taking 500 mg of vitamin C daily. Vitamin C facilitates an increase in blood glutathione levels by supplying the body with a nutrient that is critical to the manufacture of it.

In addition, to vitamin C, dietary sources of glutathione and several other nutritional compounds can help increase glutathione levels including N-acetylcysteine (NAC), alpha-lipoic acid, glutamine, methionine, and undenatured whey protein (Bounous, G., and Gold, P., The biological activity of undenatured dietary whey proteins [Immunocal]: role of glutathione, Clin. Invest. Med. (1991) 14(4):296-309.). N-acetylcysteine has been used in combination with glutamic acid (or glutamine) and glycine (Clark, J. at www.cfsn.com) and in addition, NAC has been studied in combination with dietary proteins (Quig, D., Cysteine metabolism and metal toxicity, Alternative Medicine Review (1998) 3(4):262-270.).

HERBS: The herb milk-thistle, an excellent source of the antioxidant compound silymarin may help to prevent glutathione depletion in the liver. Silymarin is many times more potent in antioxidant activity than the better known antioxidant vitamins E and vitamin C. The protective effect of silymarin against liver damage has been demonstrated in a number of scientific studies. Silymarin has been shown to protect against liver damage by extremely toxic chemicals (this toxicity is mediated by their ability to produce dangerous and destructive unstable compounds called free radicals) including amanita toxin, carbon tetrachloride, galactosamine, and praseodymium nitrate. Silymarin enhances detoxification in the liver by preventing the depletion of glutathione.

Glutathione in the liver is essential to the liver's ability to detoxify. The higher the liver glutathione content, the greater the liver's capacity to detoxify harmful chemicals. Chemicals which can damage the liver, (including alcohol and acetominophen), cause the concentration of glutathione in the liver is substantially reduced, making the hepatocytes (liver cells) susceptible to damage. Silymarin not only prevents the depletion of glutathione induced by alcohol and other toxins (Chrungoo VJ et al. Indian J Exp Biol. 1997 Jun;35(6):611-7.), but can increase the level of glutathione in the cells of the liver (hepatocytes) (Valenzuela A et al. Planta Med. 1989 Oct;55(5):420-2.), and possibly by up to 35%.

Curcumin may also be useful as an agent to increase tissue glutathione levels (Dickinson, D.A., Iles, K.E., Zhang, H., Blank, V., and Forman, H.J., Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression, FASEB J. (2003) 17(3):473-475.)

Alpha Lipoic Acid has also demonstrated it's ability to increase glutathione levels and act as a potent antioxidant in numerous scientific studies.

VITAMINS & MINERALS: vitamin B6, riboflavin, and selenium are required in the manufacture of glutathione, and adequate dietary consumption of foods rich in (or supplementation with) these vitamins and minerals can help the body to optimize glutathione production.

MILK PRODUCTS & MEAT:Dietary glutathione occurs in highest amounts in fresh (uncooked) meats, in moderate amounts in certain raw fruits and vegetables, and is absent or found only in small amounts in grains and pasteurized dairy products (JONES DP, COATES RJ, FLAGG EW, et al. (1992) Glutathione in Foods listed in the National Cancer Institute's Health Habits and History Food Frequency Questionnaire. Nutr Cancer 17: 57-75 ). Foods richest in sulfur-containing amino acids are usually the best source of glutathione. Although undenatured whey protein is one of the best precursors (building blocks) for glutathione, it contains only moderate levels of naturally occuring glutathione. Freshly prepared (rare or raw) meats, raw (unpasturized) milk, and raw eggs are also an especially rich source of glutathione. Cooking reduces glutathione content, and storage also impacts the glutathione content of foods. In human breast milk put aside for later use by breast-fed babies, a 73-79% loss of glutathione occurred when the milk was either kept at room temperature or refrigerated for two hours. (Ankrah NA, Appiah-Opong R, Dzokoto C. Human breastmilk storage and the glutathione content. J Trop Pediatr. 2000;46(2):111-3.)

FRUITS & VEGETABLES: Fresh fruits and vegetables provide excellent levels of glutathione, but cooked foods contained far less or none at all, and highly processed foods contain less than minimally processed cooked foods. Glutathione assays of fruits and vegetables may yield contrasting results because glutathione levels vary both diurnally (KOIKE S, PATTERSON BD (1988) Diurnal variation of glutathione levels in tomato seedlings. Hort Sci 23: 713-714; SCHUPP R, RENNENBERG H (1988) Diurnal changes in the glutathione content of spruce needles (Picea abies L.) Plant Sci 57: 113-117 ) with the stage of development of the plant (EARNSHAW BA, JOHNSON MA (1987) Control of wild carrot somatic embryo development by antioxidants. Plant Physiol 85: 273-276;), and due to various environmental factors (DE KOK LJ, DE KAN PJL, TANCZOS OG, KUIPER PJC (1981) Sulphate-induced accumulation of glutathione and frost-tolerance of spinach leaf tissue. Physiol Plant 53: 435-438; WISE RR, NAYLOR AW (1987) Chilling-enhanced photooxidation. The peroxidative destruction of lipids during chilling injury to photosynthesis and ultrastructure. Plant Physiol 83: 272-277).

Asparagus contains more glutathione than all other fruits and vegetables analyzed to date. (Jones, D.P. and others: Glutathione in foods listed in the National Cancer Institute's health habits and history food frequency questionnaire, Nutrition and Cancer 17 (1), p. 57, 1992.) In a study which compared the overall antioxidant activity of potatoes, bell peppers, carrots, onions and broccoli, potatoes ranked second highest after broccoli.

Per serving, asparagus, avocadoes, asparagus, squash, okra, cauliflower, broccoli, potatoes, spinach, walnuts, garlic, and raw tomatoes have the highest glutathione content compared to other vegetables and are particularly rich dietary sources of glutathione (please see the Table 1. below).

Table 1. Comparison of Glutathione in Fresh vs. Cooked Foods
(in milligrams per 3 1/2 oz (100 g) serving)

Food Glutathione Content
Apples Uncooked: 21.0 mg Cooked: 0.0 mg
Carrots Uncooked: 74.6 mg Cooked: 0.0 mg
Grapefruit Uncooked: 70.6 mg Cooked: 0.0 mg
Spinach Uncooked: 166 mg Cooked: 27.1 mg
Spinach (4) Uncooked: 9.65 mg Cooked: N/A mg
Tomatoes Uncooked: 169 mg Cooked: 0.0 mg
Asparagus (4) Uncooked: 28.3 mg Cooked: N/A mg
Avocado (4) Uncooked: 27.7 mg Cooked: N/A mg
Purslane (4) Uncooked: 14.81 mg Cooked: N/A mg

(1). JONES DP, COATES RJ, FLAGG EW, et al. (1992) Glutathione in Foods listed in the National Cancer Institute's Health Habits and History Food Frequency Questionnaire. Nutr Cancer 17: 57-75

(2). BLOCK G, DRESSER CM, HARTMAN AM, CARROLL MD (1985) Nutrient sources in the American diet: Quantitative data from the NHANES II Survey. I. Vitamins and Minerals. Am J Epidemiol 122: 13-26

(3). BLOCK G, DRESSER CM, HARTMAN AM, CARROLL MD (1985) Nutrient sources in the American diet: Quantitative data from the NHANES II Survey. Macronutrients and Fats. Am J Epidemiol 122: 27-40

(4) SIMOPOULOS AP, NORMAN HA, GILLASPY JE (1995) Purslane in human nutrition and its potential for world agriculture. World Rev Nutr Diet 77: 47-74

Posted at: http://www.nutritionadvisor.com/glutathione_foods.php; http://www.nutritionadvisor.com/glutathione_foods.php

Dr. Petrosino received his Baccalaureate degree from Penn State University in 1975, pursued his Masters degree with honors at Penn State in 1978, and graduated Summa Cum Laude with a Doctorate in Nutrition from Lasalle University (Mandeville) in 1995. His doctoral dissertation examined the effects of race and poverty on cardiovascular health. He was an Adjunct Professor of Nutrition at LaSalle University (1995-1999); a member of the National Institutes of Health (NIH) Consensus Development Committee on Cardiovascular Disease; a Professional Member and Charter Member of the American Heart Association Scientific Council on Epidemiology and Prevention of Cardiovascular Disease; a Professional Member and Charter Member of the American Heart Association Scientific Council on Nutrition, Physical Activity and Metabolism; a Professional Member of the American Heart Association Interdisciplinary Working Group on Functional Genomics and Translational Biology; an Allied Health Care Practitioner member of the American Preventive.....

eco-friendly cleaning service Buffalo Grove ..

In The News:

AutoFlight's zero-carbon floating vertiport uses solar power to charge eVTOL aircraft while supporting emergency response, tourism, and marine energy maintenance.

A new phone return scam targets recent buyers with fake carrier calls. Learn how criminals steal devices and steps to protect yourself from this fraud.

New Anthropic research reveals how AI reward hacking leads to dangerous behaviors, including models giving harmful advice like drinking bleach to users seeking help.

The Fox News AI Newsletter gives readers the latest AI technology advancements, covering the challenges and opportunities AI presents.

Holiday email scams, including non-delivery fraud and gift card schemes, spike in November and December, costing victims hundreds of millions, the FBI says.

Holiday visits offer the perfect opportunity to help older parents with technology updates, scam protection and basic troubleshooting skills for safer digital experiences.

Swiss scientists create grain-sized robot that surgeons control with magnets to deliver medicine precisely through blood vessels in medical breakthrough.

Researchers exploited WhatsApp's API vulnerability to scrape 3.5 billion phone numbers. Learn how this massive data breach happened and protect yourself.

Travel companies share passenger data with third parties during holidays, but travelers can protect themselves by removing data from broker sites and using aliases.

Xpeng's humanoid robot moves so realistically that crowds believed it was fake, marking a major advancement in robotics technology ahead of 2026 commercial launch.

Researchers discover phishing scam using invisible characters to evade email security, with protection tips including password managers and two-factor authentication.

iPhone and Android users can reduce battery drain and data usage by restricting Background App Refresh to Wi-Fi connections instead of mobile networks.

Scammers nearly stole an Apple account by exploiting the support system with authentic-looking tickets and phone calls, users can protect themselves with safety steps.

FoloToy restored sales of its AI teddy bear Kumma after a weeklong suspension following safety group findings of risky and inappropriate responses to children.

Threat intelligence firm Synthient uncovers one of the largest password exposures ever, prompting immediate security recommendations.

Viral video shared by Elon Musk shows Tesla's Optimus humanoid robots performing tasks from cooking to construction, garnering over 58.5 million views on social media.

Chinese hackers used Anthropic's Claude AI to launch autonomous cyberattacks on 30 organizations worldwide, marking a major shift in cybersecurity threats.

Apple's new Sleep Score feature gives you a rating for your nightly rest quality. Learn how to set it up on your Apple Watch and iPhone today.

Essential phone settings to enable before losing your device, including Find My network, location services and security features for iPhone and Android.

The Fox News AI Newsletter gives readers the latest AI technology advancements, covering the challenges and opportunities AI presents.

Cybersecurity research shows weak passwords remain a major threat, with simple patterns and number sequences putting millions of accounts at risk.

New Android malware BankBot YNRK silences phones, steals banking data and drains crypto wallets automatically. Learn how this advanced threat works.

FDA approves first human trial for Paradromics' brain-computer interface that could restore speech for paralyzed patients through neural technology.

New phishing platform QRR targets Microsoft 365 users across 1,000 domains in 90 countries. Learn how to spot fake login pages and protect your accounts.

OpenTable now uses AI to track your dining habits and share insights with restaurants. Learn what data they collect and how to protect your privacy.