Drug testing

Male Infertility and Glutathione

Are You Half The Man Your Father Was?

It is a well-known fact that sperm counts have dropped by half in the last 50 years, and that modern men have 20 percent less semen volume than their fathers (BMJ, 1992, volume 305).

A recent report from researchers in Aberdeen presented preliminary data that suggests the sperm concentration of the men seen in their clinic had declined by 29% over the past 14 years. (British Fertility Society; 5 January 2004)

Persistent organic pollutants (POPs) and endocrine-disrupting chemicals from normal, everyday plastics are known to cause reproductive damage, as documented in Theo Colborn's book "Our Stolen Future."

Damage to sperm caused by exposure to common chemicals like alcohol, pesticides in food, has been linked to lowered intelligence and behavioral disorders in children.

Lifestyle risk factors known to decrease sperm quality include

> Cigarette smoking

> Alcohol consumption

> Chronic stress

> Nutritional deficiencies.

Other reasons for infertility include congenital factors, and health conditions like prostatitis and diabetes that can affect sperm production.

Pollution is stealing our future, and there's little anyone can do to avoid it. There may not be a lot you can do to reduce your exposure to persistent environmental toxins.

But there are definite measures you can take to reduce the impact of the environmental pollutants and toxins on your body.

You can prevent and, to a certain extent, repair the damage they cause to your body, through a better lifestyle and nutrition.

Some nutritional therapies and antioxidants that have proven beneficial in treating male infertility and improving sperm counts, sperm morphology and motility include:

> Carnitine

> Arginine

> Zinc

> Selenium

> Vitamin B-12

> Vitamin C

> Vitamin E

> Glutathione

> Coenzyme Q10

Studies show that anti-oxidant supplementation - glutathione in particular - can improve sperm quality, and possibly increase your chances of conceiving.

If you smoke, drink, are exposed to stress, chemicals, radiation, pesticides or take medication or drugs (like sulfasalazine, ketoconazole, azulfidine, anabolic steroids, marijuana) that affect fertility, you should consider taking an antioxidant supplement to reverse some of the damage.

Why are Antioxidants Important for Sperm Quality?

Mammalian spermatozoa are coated by a membrane rich in polyunsaturated fatty acids. These fatty acids are extremely susceptible to oxidative damage by free radicals or Reactive Oxygen Species (ROS) by a process called lipid peroxidation (LPO).

Lipid peroxidation damages the sperm cell membrane. It is considered to be the key mechanism of ROS-induced sperm damage and leads to

> Loss of sperm motility

> Abnormal sperm morphology

> Reduced capacity for oocyte penetration

> Infertility

To protect sperm from damage, the body depends on powerful antioxidant enzymes in the body such as superoxide dismutase (SOD), catalase, and glutathione peroxidase/reductase (GPX/GRD).

Seminal plasma and spermatozoa have several antioxidant enzymes - glutathione peroxidase, glutathione reductase, superoxide dismutase.

Some amount of all the antioxidant enzymes, which may protect spermatozoa from oxidative attack, are also made by the epididymis during storage.

The glutathione peroxidase/reductase enzymes play a central role in the defense against oxidative damage in human sperm.

Why is Glutathione important for Sperm Quality and Fertility?

A decrease in levels of reduced glutathione (GSH) during sperm production is known to disrupt the membrane integrity of spermatozoa due to increased oxidative stress.

Intracellular glutathione levels of spermatozoa are known to be decreased in certain populations of infertile men. Compared with a control group, the infertile men in all groups had significantly higher levels of ROS and lower levels of total antioxidants.

There is strong clinical evidence to show that men diagnosed with infertility have high levels of oxidative stress that may impair the quality of their sperm.

In some groups, higher levels of ROS were associated with lower sperm counts and defective sperm structure, while lower antioxidant levels correlated with reduced sperm movement.

Previous evidence has also shown that oxidative stress can decrease a sperm's life span, its motility, and its ability to penetrate the oocyst, or egg cell.

Up to 40% of men with unexplained male infertility have higher levels of free radical activity in their bodies.

Because men with high levels of ROS have a seven-fold lower likelihood of inducing a pregnancy than men with lower levels, researchers recommend that treatment for infertile men should include strategies to reduce oxidative stress and improve sperm quality.

How can Glutathione help in the Treatment of Infertility?

Glutathione is not only vital to sperm antioxidant defenses, but selenium and glutathione are essential to the formation of "phospholipid hydroperoxide glutathione peroxidase" - an enzyme present in spermatids - which becomes a structural protein in the mid-piece of mature spermatozoa.

When either substance is deficient, it can lead to instability of the mid-piece of the spermatozoa, resulting in defective motility.

Free radical scavengers - such as glutathione - that restore the structure and function of poly-unsaturated fatty acids (PUFA) in the cell membrane, can be used to treat these cases.

In a double-blind cross-over study of twenty infertile men, treatment with glutathione led to a statistically significant improvement of the sperm quality.

The study concerned men in whom the sperm quality was poor due to unilateral varicocele or germ-free genital tract inflammation - two conditions in which ROS or other toxic compounds are indicated as causative factors.

Treatment with glutathione was also found to have a statistically significantly positive effect on sperm motility (in particular forward motility) and on sperm morphology.

The findings of these studies indicate that glutathione therapy could represent a possible therapeutical tool in cases where ROS or exposure to toxins is the probable cause of infertility.

Read the complete report with references on Male Infertility and Glutathione

Copyright ? 2004 Priya Shah

_____________________________________________

About the author:
Priya Shah is the Editor of The Glutathione Report, a newsletter featuring regular updates on the health benefits of glutathione. Get a Free report on Glutathione in Health and Disease
____________________________________________

Butler wedding limousine ..
In The News:

New information released by the World Health Organization (WHO) and U.S. Centers for Disease Control and Prevention (CDC) shows future prioritization for a potential coronavirus vaccine could be fraught with peril.
Heat waves are increasing in intensity and frequency in most parts of the world since the 1950s, a new study has found.
Even the sickest COVID-19 patients produce T cells to battle the virus, a new study reveals.
The last known members of the Indigenous Beothuk people of Newfoundland were thought to have died out 200 years ago. But genes from these people have been found in a man living in Tennessee today, researchers reported.
Archaeologists in Spain are continuing their hunt for the bones of “Red Hugh,” a 16th-century Irish chieftain who is said to be buried in the city of Valladolid.
Hundreds of elephants have mysteriously dropped dead in Botswana, leaving wildlife experts and government officials searching for answers.
A new study noted that global warming linked to human activity has wiped out the previous 6,500 years of natural global cooling.
Skywatchers are in for a treat on July 4 when the buck moon, or July full moon, rises in the sky. There will also be a partial lunar eclipse.
Remarkable photos show a group of cows walking along a nature reserve, including one looking to get a free meal.
In 2019, scientists witnessed a massive star 2.5 million times brighter than the sun disappear without a trace.

Power of Oatmeal

Come on, guys and gals. Those Trix are for kids.And... Read More

High Acid Levels Lead to Cardiovascular Disease

THE RISKWhen you consume food that's high in acid or... Read More

Understanding Cholesterol Levels and Decrease the Risk of Heart Attacks and Strokes

What is Cholesterol?Before we go into how to reduce your... Read More

A Consumers Guide to Soy Terms

Although you may have heard about soy and all of... Read More

What?s Causing Your Energy Drain?

This is such a busy time of year, isn't it?... Read More

What is the Cause?

The question most people think they need an answer to... Read More

Dietary Sources of Glutathione

DIETARY SOURCES OF GLUTATHIONE: Glutathione (GSH) is an antioxidant and... Read More

Pineapples: The Healing Fruit Of The Tropics (Includes A Recipe For Pina-Banana Orange Smoothie)

For a natural and tasty way to improve your health... Read More

Five Reasons You Should Drink More Water

I know you've heard this many times - "Drink more... Read More

The Wonderful Benefits of the Mediterranean Diet

The Mediterranean Diet is now recognized as one of the... Read More

Is Eating a Raw Food Diet Actually Healthy for You?

Whatever diet you choose to live by, the food you... Read More

Sports Nutrition Made Simple

Following these simple nutrition guidelines will allow you to lose... Read More

Eat and Lose Weight - Its All in those MCTs

Can You Lose Weight Through Eating?You get fat when you... Read More

Diet and Eczema

Much controversy and argument surrounds the idea that food may... Read More

Healthy Eating Myths Shattered

Salt does Not Cause High Blood Pressure. Some things you... Read More

Calorie Deficit

I am sure you have heard you have to build... Read More

The Crucial Role of the Salt in Our Health

Salt is vital for our health. Right now, you have... Read More

Simple Easy Health and Home Fixes From The Days Gone By

How did we cure ourselves of many aches pains and... Read More

Understanding Vegetarianism

Like the Sun, Moon, and Earth, there are three kinds... Read More

What is Organic Food?

"Organic" has some quite specific legal definitions in most developed... Read More

The Four Cornerstones of Nutrition

What is nutrition? We hear so many reports today on... Read More

Is Chocolate A New Health Food?

Could it be possible that our beloved chocolate may actually... Read More

Cherries - A Natural Joint Pain Killer

Fruit Advantage Tart Cherry capsules are a nutritious, all-natural alternative... Read More

The Virtues of Water

Did you know that much of our dry skin comes... Read More

Dont Allow Your Food To Control You

Food addiction isn't a problem. Pretending like you can't live... Read More

Arrowsmith private aviation FBO ground transportation ..