Drug testing

Dietary Sources of Glutathione

DIETARY SOURCES OF GLUTATHIONE: Glutathione (GSH) is an antioxidant and detoxifying agent whose protective role has been demonstrated in numerous clinical studies. GSH is synthesized rapidly in the liver, kidneys, and other tissues of the body, including the gastrointestinal tract. This process is effected by aging and disease, as both of these conditions result in reduced tissue and blood levels of glutathione. Dietary forms of glutathione are efficiently absorbed into the blood, however the same is not true for glutathione supplements in humans.

When healthy subjects were given a single dose of up to 3,000 mg of glutathione researchers found there was no increase in blood glutathione levels. (Witschi A, Reddy S, Stofer B, Lauterburg BH. The systemic availability of oral glutathione. Eur J Clin Pharmacol 1992;43(6):667-9.) The authors of this study concluded "it is not feasible to increase circulating glutathione to a clinically beneficial extent by the oral administrating of a single dose of 3 g of glutathione." Johnson and coworkers (Johnston CJ, Meyer CG, Srilakshmi JC. Vitamin C elevates red blood cell glutathione in healthy adults. Am J Clin Nutr 58:103-5, 1993) found that blood glutathione levels rose nearly 50% in healthy individuals taking 500 mg of vitamin C daily. Vitamin C facilitates an increase in blood glutathione levels by supplying the body with a nutrient that is critical to the manufacture of it.

In addition, to vitamin C, dietary sources of glutathione and several other nutritional compounds can help increase glutathione levels including N-acetylcysteine (NAC), alpha-lipoic acid, glutamine, methionine, and undenatured whey protein (Bounous, G., and Gold, P., The biological activity of undenatured dietary whey proteins [Immunocal]: role of glutathione, Clin. Invest. Med. (1991) 14(4):296-309.). N-acetylcysteine has been used in combination with glutamic acid (or glutamine) and glycine (Clark, J. at www.cfsn.com) and in addition, NAC has been studied in combination with dietary proteins (Quig, D., Cysteine metabolism and metal toxicity, Alternative Medicine Review (1998) 3(4):262-270.).

HERBS: The herb milk-thistle, an excellent source of the antioxidant compound silymarin may help to prevent glutathione depletion in the liver. Silymarin is many times more potent in antioxidant activity than the better known antioxidant vitamins E and vitamin C. The protective effect of silymarin against liver damage has been demonstrated in a number of scientific studies. Silymarin has been shown to protect against liver damage by extremely toxic chemicals (this toxicity is mediated by their ability to produce dangerous and destructive unstable compounds called free radicals) including amanita toxin, carbon tetrachloride, galactosamine, and praseodymium nitrate. Silymarin enhances detoxification in the liver by preventing the depletion of glutathione.

Glutathione in the liver is essential to the liver's ability to detoxify. The higher the liver glutathione content, the greater the liver's capacity to detoxify harmful chemicals. Chemicals which can damage the liver, (including alcohol and acetominophen), cause the concentration of glutathione in the liver is substantially reduced, making the hepatocytes (liver cells) susceptible to damage. Silymarin not only prevents the depletion of glutathione induced by alcohol and other toxins (Chrungoo VJ et al. Indian J Exp Biol. 1997 Jun;35(6):611-7.), but can increase the level of glutathione in the cells of the liver (hepatocytes) (Valenzuela A et al. Planta Med. 1989 Oct;55(5):420-2.), and possibly by up to 35%.

Curcumin may also be useful as an agent to increase tissue glutathione levels (Dickinson, D.A., Iles, K.E., Zhang, H., Blank, V., and Forman, H.J., Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression, FASEB J. (2003) 17(3):473-475.)

Alpha Lipoic Acid has also demonstrated it's ability to increase glutathione levels and act as a potent antioxidant in numerous scientific studies.

VITAMINS & MINERALS: vitamin B6, riboflavin, and selenium are required in the manufacture of glutathione, and adequate dietary consumption of foods rich in (or supplementation with) these vitamins and minerals can help the body to optimize glutathione production.

MILK PRODUCTS & MEAT:Dietary glutathione occurs in highest amounts in fresh (uncooked) meats, in moderate amounts in certain raw fruits and vegetables, and is absent or found only in small amounts in grains and pasteurized dairy products (JONES DP, COATES RJ, FLAGG EW, et al. (1992) Glutathione in Foods listed in the National Cancer Institute's Health Habits and History Food Frequency Questionnaire. Nutr Cancer 17: 57-75 ). Foods richest in sulfur-containing amino acids are usually the best source of glutathione. Although undenatured whey protein is one of the best precursors (building blocks) for glutathione, it contains only moderate levels of naturally occuring glutathione. Freshly prepared (rare or raw) meats, raw (unpasturized) milk, and raw eggs are also an especially rich source of glutathione. Cooking reduces glutathione content, and storage also impacts the glutathione content of foods. In human breast milk put aside for later use by breast-fed babies, a 73-79% loss of glutathione occurred when the milk was either kept at room temperature or refrigerated for two hours. (Ankrah NA, Appiah-Opong R, Dzokoto C. Human breastmilk storage and the glutathione content. J Trop Pediatr. 2000;46(2):111-3.)

FRUITS & VEGETABLES: Fresh fruits and vegetables provide excellent levels of glutathione, but cooked foods contained far less or none at all, and highly processed foods contain less than minimally processed cooked foods. Glutathione assays of fruits and vegetables may yield contrasting results because glutathione levels vary both diurnally (KOIKE S, PATTERSON BD (1988) Diurnal variation of glutathione levels in tomato seedlings. Hort Sci 23: 713-714; SCHUPP R, RENNENBERG H (1988) Diurnal changes in the glutathione content of spruce needles (Picea abies L.) Plant Sci 57: 113-117 ) with the stage of development of the plant (EARNSHAW BA, JOHNSON MA (1987) Control of wild carrot somatic embryo development by antioxidants. Plant Physiol 85: 273-276;), and due to various environmental factors (DE KOK LJ, DE KAN PJL, TANCZOS OG, KUIPER PJC (1981) Sulphate-induced accumulation of glutathione and frost-tolerance of spinach leaf tissue. Physiol Plant 53: 435-438; WISE RR, NAYLOR AW (1987) Chilling-enhanced photooxidation. The peroxidative destruction of lipids during chilling injury to photosynthesis and ultrastructure. Plant Physiol 83: 272-277).

Asparagus contains more glutathione than all other fruits and vegetables analyzed to date. (Jones, D.P. and others: Glutathione in foods listed in the National Cancer Institute's health habits and history food frequency questionnaire, Nutrition and Cancer 17 (1), p. 57, 1992.) In a study which compared the overall antioxidant activity of potatoes, bell peppers, carrots, onions and broccoli, potatoes ranked second highest after broccoli.

Per serving, asparagus, avocadoes, asparagus, squash, okra, cauliflower, broccoli, potatoes, spinach, walnuts, garlic, and raw tomatoes have the highest glutathione content compared to other vegetables and are particularly rich dietary sources of glutathione (please see the Table 1. below).

Table 1. Comparison of Glutathione in Fresh vs. Cooked Foods
(in milligrams per 3 1/2 oz (100 g) serving)

Food Glutathione Content
Apples Uncooked: 21.0 mg Cooked: 0.0 mg
Carrots Uncooked: 74.6 mg Cooked: 0.0 mg
Grapefruit Uncooked: 70.6 mg Cooked: 0.0 mg
Spinach Uncooked: 166 mg Cooked: 27.1 mg
Spinach (4) Uncooked: 9.65 mg Cooked: N/A mg
Tomatoes Uncooked: 169 mg Cooked: 0.0 mg
Asparagus (4) Uncooked: 28.3 mg Cooked: N/A mg
Avocado (4) Uncooked: 27.7 mg Cooked: N/A mg
Purslane (4) Uncooked: 14.81 mg Cooked: N/A mg

(1). JONES DP, COATES RJ, FLAGG EW, et al. (1992) Glutathione in Foods listed in the National Cancer Institute's Health Habits and History Food Frequency Questionnaire. Nutr Cancer 17: 57-75

(2). BLOCK G, DRESSER CM, HARTMAN AM, CARROLL MD (1985) Nutrient sources in the American diet: Quantitative data from the NHANES II Survey. I. Vitamins and Minerals. Am J Epidemiol 122: 13-26

(3). BLOCK G, DRESSER CM, HARTMAN AM, CARROLL MD (1985) Nutrient sources in the American diet: Quantitative data from the NHANES II Survey. Macronutrients and Fats. Am J Epidemiol 122: 27-40

(4) SIMOPOULOS AP, NORMAN HA, GILLASPY JE (1995) Purslane in human nutrition and its potential for world agriculture. World Rev Nutr Diet 77: 47-74

Posted at: http://www.nutritionadvisor.com/glutath ione_foods.php; http://www.nutritionadvisor.com/biography.php

Dr. Petrosino received his Baccalaureate degree from Penn State University in 1975, pursued his Masters degree with honors at Penn State in 1978, and graduated Summa Cum Laude with a Doctorate in Nutrition from Lasalle University (Mandeville) in 1995. His doctoral dissertation examined the effects of race and poverty on cardiovascular health. He was an Adjunct Professor of Nutrition at LaSalle University (1995-1999); a member of the National Institutes of Health (NIH) Consensus Development Committee on Cardiovascular Disease; a Professional Member and Charter Member of the American Heart Association Scientific Council on Epidemiology and Prevention of Cardiovascular Disease; a Professional Member and Charter Member of the American Heart Association Scientific Council on Nutrition, Physical Activity and Metabolism; a Professional Member of the American Heart Association Interdisciplinary Working Group on Functional Genomics and Translational Biology; an Allied Health Care Practitioner member of the American Preventive.....

In The News:

The current heatwave in the British Isles has revealed a host of long-hidden historical sites that have suddenly become visible through the parched earth.
Archaeologists in Ireland have uncovered a megalithic tomb containing two burial chambers, complete with elaborate carvings.
A team of scientists made an enormous discovery when they recently uncovered a "quadrillion" tons of diamonds,buried more than 100 miles below Earth's surface, according to a new study.
Doctor Richard Harris was thought to be the one who decided which boy was saved first, but new details have emerged.
Astronomers in Australia are eager for a special celestial alignment this week that could tell them more about one of the most intriguing candidates for hosting life beyond Earth.
Attention, anglers in Pennsylvania: A northern snakehead, also known as “frankenfish,” was found recently in Octoraro Creek in Little Britain Township.
As hurricanes continue to cause greater impact from factors such as climate change, NASA's new hurricane-tracking satellites could be up and running by as early 2019.
Scientists have discovered 12 previously unknown moons orbiting Jupiter, and one of them is a real oddball.
Once again, scientists have shown that Albert Einstein's theory of special relativity is right — this time, thanks to a particle detector buried deep beneath Antarctica.
Scientists searching for sea snakes never expected to stumble across this find.

Aggressive Behaviour Seems To Be Triggered By Early Age Diet

The fact that diet directly affects behaviour is no news,... Read More

3 Things You Want to Know About Cholesterol

You wouldn't judge a book by its cover, would you?You... Read More

Debunking the Myth About Bottled Water: Is It Really Safer for Your Kids?

When you actually sit down and think about it, bottled... Read More

10 Flaxseed Facts to Improve Your Nutrition

Flaxseeds may be the smallest seeds you will find in... Read More

Refrigerator Water Filters vs. Bottled Water: Round 1

Water is the single most important element for human existence,... Read More

Aging Gracefully with the Aid of Various Nutrients

During the past thirty years there has been a steadily... Read More

Hypertension -Twelve Simple Things You Can Do To Lower Your Blood Pressure

Headlines:Nearly a quarter of American adults just got diagnosed with... Read More

Eliminate Sugar and Lose Weight

If you want to lose weight, there is one thing... Read More

Sugar, America?s Drug of Choice

Many people use sugar as medicine. Sugar tends to change... Read More

Autism and ADHD Linked to Child Vaccines

In a study review conducted by David A. Geier, B.A.... Read More

Preventing Heart Disease: What Not To Eat

About 12.6 million Americans currently have heart disease.1.1 million Americans... Read More

Good Eggs -- Rediscover The Simple Pleasures of Eggs!

Health food or heart attack on a plate? Eggs had... Read More

Poor Dental Hygiene May Account for Poor Health

Bright white teeth and fresh breath does not necessarily... Read More

Protective Effects of Omega-3 Fatty Acids

Omega-3 appear to reduce the risk of heart attack. A... Read More

Lesser of Two Evils: Splenda or Equal?

While packages of the artificial sweetener Splenda claim, "made from... Read More

You Are What You Eat

You really are what you eat. You are also very... Read More

Is Eating a Raw Food Diet Actually Healthy for You?

Whatever diet you choose to live by, the food you... Read More

Water - The Natural Choice

Proper hydration is extremely important during exercise. Adequate fluid intake... Read More

Immunity and the Immune System

Since the 1930's the western diet has dramatically changed. This... Read More

Seven Secret Agents That Can Help You Live To 120

You know about Vitamins A,C, D, E ,and the B's... Read More

Chew Your Food

I am going to share with you possibly the most... Read More

Healthy Eating Myths Destroyed

Some of the things you think you know that just... Read More

You are Closer to Being Vitamin C Deficient Than You Think

Okay, so you think you are doing pretty well with... Read More

Learn the Basics of a Successful Low Cholesterol Diet

Understanding What a Low Cholesterol Diet isBasically, in order to... Read More

A Look at Lactose Intolerance

Lactose is the primary carbohydrate in milk. Cow's milk contains... Read More

energy efficient street lights cree led street lights Pete's produce ..